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Malignant cachexia

MedGen UID:
1703849
•Concept ID:
C1391732
•
Sign or Symptom
Synonyms: Cachexia due to malignant neoplastic disease; Muscle atrophy due to malignant neoplastic disease
SNOMED CT: Malignant cachexia (788876001); Cachexia due to malignant neoplastic disease (788876001); Muscle atrophy due to malignant neoplastic disease (788876001)

Professional guidelines

PubMed

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
ESPEN practical guideline: Clinical Nutrition in cancer.
Muscaritoli M, Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Hütterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Mühlebach S, Oldervoll L, Ravasco P, Solheim TS, Strasser F, de van der Schueren M, Preiser JC, Bischoff SC
Clin Nutr 2021 May;40(5):2898-2913. Epub 2021 Mar 15 doi: 10.1016/j.clnu.2021.02.005. PMID: 33946039
ESPEN guidelines on nutrition in cancer patients.
Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Fearon K, Hütterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Mühlebach S, Muscaritoli M, Oldervoll L, Ravasco P, Solheim T, Strasser F, de van der Schueren M, Preiser JC
Clin Nutr 2017 Feb;36(1):11-48. Epub 2016 Aug 6 doi: 10.1016/j.clnu.2016.07.015. PMID: 27637832

Recent clinical studies

Etiology

Cachexia in patients with chronic pancreatitis and pancreatic cancer: impact on survival and outcome.
Bachmann J, Büchler MW, Friess H, Martignoni ME
Nutr Cancer 2013;65(6):827-33. doi: 10.1080/01635581.2013.804580. PMID: 23909726
Risk analysis in resection of squamous cell carcinoma of the esophagus.
Law SY, Fok M, Wong J
World J Surg 1994 May-Jun;18(3):339-46. doi: 10.1007/BF00316812. PMID: 8091773
A comparison of outcome after resection for squamous cell carcinomas and adenocarcinomas of the esophagus and cardia.
Law SY, Fok M, Cheng SW, Wong J
Surg Gynecol Obstet 1992 Aug;175(2):107-12. PMID: 1636132
Early and late outcome after diagnostic thoracoscopy and talc pleurodesis.
Ohri SK, Oswal SK, Townsend ER, Fountain SW
Ann Thorac Surg 1992 Jun;53(6):1038-41. doi: 10.1016/0003-4975(92)90384-g. PMID: 1596125
Palliative intubation for dysphagia in patients with carcinoma of the esophagus.
Liakakos TK, Ohri SK, Townsend ER, Fountain SW
Ann Thorac Surg 1992 Mar;53(3):460-3. doi: 10.1016/0003-4975(92)90269-a. PMID: 1371664

Diagnosis

Obstructive jaundice caused by lymphatic remetastasis from the hepatic metastasis of rectosigmoid cancer.
Ishizaki N, Hamada N, Kadono J, Nakamura N, Taira A
J Hepatobiliary Pancreat Surg 2001;8(5):469-72. doi: 10.1007/s005340100011. PMID: 11702258
Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II.
Mizuta Y, Isomoto H, Futuki Y, Ehara N, Takeshima F, Omagari K, Murase K, Yakata Y, Senjyu M, Masuda J, Ikuno N, Haraguchi M, Iwasaki K, Shimokawa I, Kohno S
J Gastroenterol 1998 Oct;33(5):761-5. doi: 10.1007/s005350050170. PMID: 9773947
Early and late outcome after diagnostic thoracoscopy and talc pleurodesis.
Ohri SK, Oswal SK, Townsend ER, Fountain SW
Ann Thorac Surg 1992 Jun;53(6):1038-41. doi: 10.1016/0003-4975(92)90384-g. PMID: 1596125

Therapy

Toxicity profile of the immunomodulatory thalidomide analogue, lenalidomide: phase I clinical trial of three dosing schedules in patients with solid malignancies.
Sharma RA, Steward WP, Daines CA, Knight RD, O'Byrne KJ, Dalgleish AG
Eur J Cancer 2006 Sep;42(14):2318-25. Epub 2006 Aug 8 doi: 10.1016/j.ejca.2006.05.018. PMID: 16899362
Early and late outcome after diagnostic thoracoscopy and talc pleurodesis.
Ohri SK, Oswal SK, Townsend ER, Fountain SW
Ann Thorac Surg 1992 Jun;53(6):1038-41. doi: 10.1016/0003-4975(92)90384-g. PMID: 1596125
Palliative intubation for dysphagia in patients with carcinoma of the esophagus.
Liakakos TK, Ohri SK, Townsend ER, Fountain SW
Ann Thorac Surg 1992 Mar;53(3):460-3. doi: 10.1016/0003-4975(92)90269-a. PMID: 1371664

Prognosis

Cachexia in patients with chronic pancreatitis and pancreatic cancer: impact on survival and outcome.
Bachmann J, Büchler MW, Friess H, Martignoni ME
Nutr Cancer 2013;65(6):827-33. doi: 10.1080/01635581.2013.804580. PMID: 23909726
Obstructive jaundice caused by lymphatic remetastasis from the hepatic metastasis of rectosigmoid cancer.
Ishizaki N, Hamada N, Kadono J, Nakamura N, Taira A
J Hepatobiliary Pancreat Surg 2001;8(5):469-72. doi: 10.1007/s005340100011. PMID: 11702258
Risk analysis in resection of squamous cell carcinoma of the esophagus.
Law SY, Fok M, Wong J
World J Surg 1994 May-Jun;18(3):339-46. doi: 10.1007/BF00316812. PMID: 8091773
A comparison of outcome after resection for squamous cell carcinomas and adenocarcinomas of the esophagus and cardia.
Law SY, Fok M, Cheng SW, Wong J
Surg Gynecol Obstet 1992 Aug;175(2):107-12. PMID: 1636132

Clinical prediction guides

Risk analysis in resection of squamous cell carcinoma of the esophagus.
Law SY, Fok M, Wong J
World J Surg 1994 May-Jun;18(3):339-46. doi: 10.1007/BF00316812. PMID: 8091773
Protein and amino acid metabolism in cancer cachexia: investigative techniques and therapeutic interventions.
Pisters PW, Pearlstone DB
Crit Rev Clin Lab Sci 1993;30(3):223-72. doi: 10.3109/10408369309084669. PMID: 8260072
Palliative laser therapy for inoperable rectal cancer--does it work? A prospective study of quality of life.
McGowan I, Barr H, Krasner N
Cancer 1989 Mar 1;63(5):967-9. doi: 10.1002/1097-0142(19890301)63:5<967::aid-cncr2820630530>3.0.co;2-e. PMID: 2464430

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